New insights of CYP1A in endogenous metabolism: a focus on single nucleotide polymorphisms and diseases

更新时间:2023-05-28

【摘要】Cytochrome P450 1A (CYP1A),one of the major CYP subfamily in humans,not only metabolizes xenobiotics including clinical drugs and pollutants in the environment,but also mediates the bio transformation of important endogenous substances.In particular,some single nucleotide polymorphisms (SNPs) for CYPIA genes may affect the metabolic ability of endogenous substances,leading to some physiological or pathological changes in humans.This review first summarizes the metabolism of endogenous substances by CYPIA,and then introduces the research progress of CYPIA SNPs,especially the research related to human diseases.Finally,the relationship between SNPs and diseases is discussed.In addition,potential animal models for CYPIA gene editing are summarized.In conclusion,CYP1A plays an important role in maintaining the health in the body.

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